BSI Lecture - Role of RNA Polymerase and Transcription in the Bacterial Nucleoid
Ding Jin , PhD, Head, Transcription Control Section, Senior Investigator, Center for Cancer Research, National Cancer Institute
Recent advances in the cell biology of E. coli RNAP and the nucleoid have shown that the distribution of RNAP, which is coupled to cell growth, plays an important role in the nucleoid dynamic structure. Emerging evidence indicates that formation of the transcription foci centered at the putative bacterial nucleolus is critical in nucleoid remodeling and influencing global gene expression. The interface between the distribution of RNAP and nucleoid organization in the cell will be discussed.