Nanotechnology and Cancer Therapeutics: Hype vs. Clinical Reality

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Venue:AHC4, Room 101

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Professor, Department of Molecular and Cellular Oncology, University of Texas, M. D. Anderson Cancer Center

Dr. Klostergaard received his Ph.D. in Chemistry from the State University of New York, Buffalo, and carried out postdoctoral work in the Roswell Park Memorial Institute (Buffalo) and the University of California, Irvine. He has been an Assistant, Associate and Full Professor in the Departments of Tumor Biology, Cancer Biology, and Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, since 1982. Dr. Klostergaard is a translational investigator, interested in targeted cancer therapeutics and associated drug delivery platforms.

In recent years his work has focused on nanoparticles as vehicles for targeted delivery. Both passive and active tumor-targeting methods are being evaluated. This presentation will discuss underlying molecular, cellular and anatomical mechanisms that contribute to the exploitability of the Enhanced Permeability and Retention (EPR) effect for cancer drug delivery, and also examine possible strategies to enhance current outcomes.